Antifungal Effect of 7-hydroxycitronellal against Candida albicans Strains
Heloísa Mara Batista Fernandes de Oliveira *
Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
Abrahão Alves de Oliveira Filho
Academic Unit Biological Sciences, Federal University of Campina Grande, Paraiba, Brazil.
José Pinto de Siqueira Júnior
Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
Edeltrudes de Oliveira Lima
Program in Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Monoterpenes, the main constituents of essential oils, are associated with antifungal, analgesic, antiepileptic, anti-inflammatory, anxiolytic and gastroprotective activities. The aim of this study was to evaluate the antifungal effects of the monoterpene 7-hydroxycitronellal against five Candida albicans strains using microdilution method. All the strains were obtained from the Laboratory of Mycology collection. Nistatin (100 UI/mL) was used as the standard drug. The monoterpene showed strong antifungal activity with MIC50 and MFC50 values of 256 and 512 µg/mL respectively. The results showed fungicidal potential of 7-hydroxycitronellal against C. albicans strains.
Keywords: Monoterpene, nistatin, antifungal, Candida albicans.