Antifungal Effect of Flavonoid 5, 7, 4’-Trimethoxyflavone against Candida krusei Strains
Abrahão Alves de Oliveira Filho *
Programin Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
Heloísa Mara Batista Fernandes
Programin Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
Janiere Pereira de Sousa
Programin Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
Gabriela Lemos de Azevedo Maia
Department of Pharmacy, Federal University of São Francisco Valley, Pernambuco, Brazil.
José Maria Barbosa Filho
Programin Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
Thais Josy Castro Freire de Assis
Academic Health Unit, Federal University of Campina Grande, Paraiba, Brazil.
Hilzeth Luna Freire Pêssoa
Programin Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
Edeltrudes Oliveira Lima
Programin Natural Products and Synthetic Bioactive, Federal University of Paraiba, Paraiba, Brazil.
*Author to whom correspondence should be addressed.
Abstract
Most of the flavonoids are considered as constitutive antimicrobial ingredients, especially those belonging to prenylated flavonoids, flavones and isoflavones. In the study, the flavonoid 5,7,4’-trimethoxyflavone was evaluated for its antifungal effects. Four fungal strains were used in the study for activities, Candida krusei – LM 9700, Candida krusei – LM 656, Candida krusei– LM 13 and Candida krusei – LM08. All the microorganism strains were obtained from the Laboratory of Mycology collection. Microdilution method was used for antifungal assay of the flavonoid. The results were also compared with the standard drug, Nistatin (100 UI/mL). The obtained results showed activity fungistatic against Candida krusei strains.
Keywords: Flavonoid, nistatin, antifungal, Candida krusei.