The Effect of Co-infection of HIV and Hepatotropic Viruses on Selected Biochemical and Haematological Markers of Patients in Northeastern Nigeria
Simon O. Obi
University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
Haruna A. Baba
Ashaka Cement Federal Medical Centre, Gombe, Nigeria.
Marycelin M. Baba *
University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
Grace I. Amilo
Department of Hematology, Nnamdi Azikwe University Awka, Ngeria.
Alhaji Bukar
University of Maiduguri Teaching Hospital, Maiduguri, Nigeria.
*Author to whom correspondence should be addressed.
Abstract
Background: As deaths caused by HIV declines with the use of HAART, liver disease associated with co-infection of HIV with hepatotropic viruses has become an increasing cause of morbidity and mortality.
Aim: To assess the effect of HIV-mono and co-infections with hepatotropic viruses on haematological and biochemical markers of the patients.
Methodology: 109 HIV patients from tertiary health facilities in northeastern Nigeria were initially screened with Immuno chromatographic kit for HIV antibody and confirmed by western blot prospectively and consecutively. However, Hepatitis B virus surface antigen (HBsAg) and Hepatitis C virus (HCV) antibody were detected on the HIV positive patients by ELISA. Blood donors served as control. The study was conducted between January and October 2012.
Results: Of the HIV patients 12.8% and 4.6% had HBsAg and HCV antibody respectively. The prevalence rate of Hepatitis B virus (HBV) infection among males was 12.8% while females had 12.9% but lower rates of HCV were obtained in both males (5.1%) and females (3.3%). However, HIV mono-infections had higher mean baseline values for haemogblobin (Hb), CD4 and platelet counts, protein C (PC) and protein S (PS) in comparison with HIV/ HBV/HCV co-infections (P<0.05). In addition, Prothrombin time and partial thromboplastin time were lower in HIV mono- infection in contrast to co-infections (P<0.05). Similarly, the mean values of Serum liver enzymes such as Aspartate transaminase (AST), Alanine transaminase (ALT), Akaline Phosphatase (ALP) and creatinine were lower in HIV mono-infection compared with HIV/HBV or HIV/HCV co-infection (P<0.05). Total white blood cell count (WBC), total cholesterol (TCH), Random blood sugar (RBS) and potassium (K+) were not significantly different (P>0.05) in both groups.
Conclusion: Co-infections of HIV and hepatotropic viruses do occur. Haematological and biochemical parameters serve as pointers for early detection of liver disease in HIV patients. The development of novel therapeutic approaches to impede co-infection of HIV and hepatotropic viruses is encouraged.
Keywords: HIV, hepatitis B virus, hepatitis C virus co-infection, haematological and biochemical markers